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What to know about BA.2, a new version of the omicron variant

“The BA. 2 descendant lineage, which differs from BA. 1 in some of the mutations, including in the spike protein, is increasing in many countries,” the WHO wrote on its website. “Investigations into the characteristics of BA. 2, including immune escape properties and virulence, should be prioritized independently (and comparatively) to BA. 1.”

Viruses mutate constantly, mostly in harmless ways. There is no current evidence that BA. 2 is more virulent, spreads faster or escapes immunity better than BA. 1.

“Variants have come, variants have gone,” said Robert Garry, a virologist at Tulane University School of Medicine. “I don’t think there’s any reason to think this one is a whole lot worse than the current version of omicron.”

BA. 2 has been detected in India, Denmark and Britain, among other countries, according to health officials and media reports abroad. In Europe, it appears the most widespread in Denmark, but that may be because the Scandinavian nation has a robust program of sequencing the virus’s genome.

Coronavirus variants like omicron, delta and mu are an expected part of the virus’s life cycle, but vaccines can prevent more infectious variants from forming. (John Farrell, Hadley Green/The Washington Post)

At least three cases have been found in the United States at Houston Methodist Hospital in Texas, which also is studying the genetic makeup of virus samples from its patients.

“The good news is we have only three,” said James Musser, director of the Center for Molecular and Translational Human Infectious Diseases Research at Houston Methodist. “We certainly do not see the 5 percent and more that is being reported in the U.K. now and certainly not the 40 percent that is being reported in Denmark.”

But Musser said BA. 2 deserves close attention because little is known about it yet.

“We know that omicron … can clearly evade preexisting immunity” from both vaccines and exposure to other variants of the virus, he said. “What we don’t know yet is whether son-of-omicron does that better or worse than omicron. So that’s an open question.”

On Monday, more than 695,000 new coronavirus infections were reported and testing shows that almost all are from omicron. Still, that total is down 13.7 percent from the week prior, according to a seven-day average of data tracked by The Washington Post.

Kristen Nordlund, a spokeswoman for the Centers for Disease Control and Prevention said, “Although the BA.2 lineage has recently increased in proportion in some countries, it remains a very low proportion of circulating viruses in the United States and globally. Currently, there are insufficient data to determine whether the BA.2 lineage is more transmissible or has a fitness advantage over the BA.1 lineage. CDC continues to monitor variants that are circulating both domestically and internationally.”

Anders Fomsgaard a virologist at the State Serum Institute in Denmark, said in an email Monday that BA. 2 has become the dominant form of the virus in his nation of nearly 6 million people, where it now accounts for about 65 percent of new cases as BA. 1 is on the decline.

At the same time, Fomsgaard said, “we are not so concerned, since we so far do not see major differences in age distribution, vaccination status, breakthrough infections and risk of hospitalization. Also, despite the high infection rate of BA. 2, the numbers of hospitalizations [in] ICUs are decreasing.”

The United Kingdom Health Security Agency identified more than 400 cases of BA. 2 in the first 10 days of January and on Friday designated BA. 2 a “virus under investigation,” according to Al Jazeera. The agency said BA. 2 has been identified in 40 countries and “there is still uncertainty around the significance of the changes to the viral genome.”

Some scientists have dubbed BA. 2 the “stealth omicron” because it has genetic traits that make it more difficult to identify the omicron form of the virus on PCR tests.

A French epidemiologist told Agence France-Presse that “what surprised us is the rapidity with which this sub-variant, which has been circulating to a great extent in Asia, has taken hold in Denmark.”

Lena H. Sun contributed to this report.

https://www.washingtonpost.com/health/2022/01/24/covid-omicron-ba2/